Duloxetine for Perioperative Pain in Hip Arthroplasty: A RCT

Exclusion Criteria

• •Previous hemiarthroplasty or THA on ipsilateral hip
• •History of Complex Regional Pain Syndrome in ipsilateral extremity
• •History of demyelinating disorder or neurologic deficit that may contribute to altered pain tolerance or sensation
• •Acute or chronic hip infection in ipsilateral extremity
• •Pregnant or breastfeeding
• •Open fracture
• •Polytrauma
• •Intravenous or drug users within 6 months of surgery
• •Liver Failure via clinical diagnosis or international normalized ratio greater than 1.5 or partial thromboplastin time greater than 40
• •Patients on selective serotonin reuptake inhibitor, serotonin norepinephrine reuptake inhibitor, monoamine oxidase inhibitor, and/or tricyclic anti-depressant
• •Severe renal dysfunctions, such as glomerular filtration rate less than 30
• •Moderate to severe depression as diagnosed by a clinician
• •Taking cytochrome P450 1A2 inhibitors and cytochrome P450 1A6 inhibitors for the duration of 5 half-lives as these drugs are clinically eliminated within 5 half-lives
• •History of uncontrolled narrow angle glaucoma