FMT+ QL1706+Bevacizumab+ XELOX as First-line Treatment for Advanced MSS-type Colon Cancer With Liver Metastasis

Exclusion Criteria

• •1. Suffered from other malignancies in the past 5 years, excluding cured basal cell carcinoma of the skin, cervical carcinoma in situ and papillary thyroid carcinoma.
• •2. Patients requiring elective surgery during the trial.
• •3. Patients who cannot take oral drugs, or have conditions that the investigator determines to significantly affect gastrointestinal absorption, such as chronic diarrhea, intestinal obstruction, etc., and are not suitable for treatment.
• •4. Patients during pregnancy (positive pregnancy test) or lactation.
• •5. Central nervous system metastasis or meningeal metastasis.
• •6. Uncontrollable bone metastasis, or patients at risk of fracture, requiring surgery, local radiation therapy.
• •7. Patients with active infection requiring systemic anti-infection treatment.
• •8. Patients with a history of immunodeficiency, including those who are positive for HIV antibody tests.
• •9. Patients with known, active autoimmune diseases.
• •10. Patients with uncontrolled active hepatitis B, patients with hepatitis C virus infection (HCV antibody positive).
• •11. A history of severe cardiovascular and cerebrovascular diseases, including but not limited to: severe arrhythmia, acute coronary syndrome within 6 months, congestive heart failure, aortic dissection, stroke, and T IA history.
• •12. Severe bleeding events occur within half a year, or high bleeding risk factors such as active digestive tract ulcers and esophageal and gastric varices due to liver cirrhosis.
• •13. Patients with diabetes who cannot be stably controlled by drugs (including insulin).
• •14. Mental or language disorders that prevent communication with the patient;
• •15. Patients participating in another clinical trial.
• •16. MSI-H/ d MMR without immunotherapy; left colorectum of Ras, Raf wild-type.
• •17. The investigator believes that the subject has other serious systemic diseases or other conditions that make him unsuitable for participation in this trial.