Multiple-biomarker Approach for Individualized Treatment of Heart Failure with Preserved Ejection Fraction

Exclusion Criteria

• •History of LVEF ≤40%
• •Scheduled for surgery or intervention for both coronary and non-coronary indication within 6 months of inclusion
• •Impaired renal function, defined as eGFR \< 20 mL/min/1.73 m2 (CKD-EPI) or requiring dialysis at the time of screening
• •Acute or chronic liver disease, defined by serum levels of transaminases or alkaline phosphatase more than three times the upper limit of normal at screening
• •COPD Gold stage IV
• •Congenital heart disease
• •Pregnancy
• •Coexistent condition with life expectancy of \<1 year
• •Unlikely to appear at all scheduled follow-up visits
• •Linguistic barrier