Dietary Protein Requirements in Adults With Facioscapulohumeral Muscular Dystrophy

Exclusion Criteria

• •Individuals who are lactating or pregnant
• •Usage of corticosteroids within 3 months of study entry or had ever taken steroids for a duration exceeding 1 year
• •On androgens or growth hormone within 6 months before screening and for duration of study; topical physiologic androgen replacement is permitted
• •On sympathomimetic agents, antidepressants, or β-receptor blockers
• •Have cardiovascular disease
• •Evidence of an alternative diagnosis other than FSHD or a coexisting myopathy or dystrophy
• •Current/active malignancy (e.g., remission less than 5 years' duration), with the exception of fully excised or treated basal cell carcinoma, cervical carcinoma in-situ, or ≤ 2 squamous cell carcinomas of the skin
• •Type 1 or type 2 diabetes mellitus
• •History of sensitivity to protein pharmaceuticals
• •Known active substance abuse, including alcohol
• •Renal impairment (serum creatinine ≥ 2 times the upper limit of normal,(ULN))
• •History of severe restrictive or obstructive lung disease, or evidence for interstitial lung disease on screening chest radiograph
• •Major surgery within 4 weeks prior to metabolic trial 1
• •Any other active or unstable medical/psychological conditions or use of medications/supplements/therapies that, in the opinion of the investigator, may adversely affect the participant's ability to complete the study or its measures or pose a significant risk to the participant.