Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
OHSU Knight Cancer Institute
With
Oregon Health and Science University
PRIMARY OBJECTIVES:
I. To assess positive VPD antibody (Ab) titers prior to and at 6 months after CAR-T therapy to evaluate the impact of CAR-T on immune responses in patients undergoing CAR-T therapy.
II. To assess the change in Ab titer to S. pneumoniae and tetanus at 6 months and 1 year post-vaccination and evaluate if titer increases are correlated to post-vaccination CD4+ count and IgG level.
OUTLINE: This is an observational study.
Patients may receive up to 3 doses of pneumococcal and/or tetanus vaccine per institutional policy of revaccination. Patients undergo blood sample collection and have medical records reviewed throughout the study.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
\* Willingness to provide written informed consent before any study-specific procedures or activities are performed
* Age ≥ 18 years of age, at the time of consent
* Documented, histologically or cytologically confirmed diagnosis of multiple myeloma (MM), diffuse large B cell lymphoma (DLBCL),follicular lymphoma (FL), mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), or small lymphocytic lymphoma (SLL), or primary mediastinal B cell lymphoma (PMBL). All number of prior lines of therapy are allowed
* History of prior vaccination against common VPD
* Approved by managing physician for CAR-T therapy, with preparative conditioning planned within the next 90 days
* Approved by managing physician for revaccination against Streptococcus pneumoniae or tetanus
You may not be if
\* Ongoing use of immunosuppressive agents or plans for immunosuppressive therapy that would interfere with interpretation of study endpoints
* Uncontrolled, intercurrent illness including, but not limited to, systemic infection, symptomatic congestive heart failure, unstable angina pectoris, or psychiatric illness/social situations that would limit compliance with study requirements or make the study procedures unadvisable
