Protecting Renal Function in Chronic Kidney Disease Patients with Isolated Nighttime Hypertension

Exclusion Criteria

• •Presence of acute kidney injury or acute renal failure;
• •History of kidney transplantation;
• •Presence of severe arrhythmias, including severe atrial fibrillation, atrioventricular (AV) block, sinoatrial (SA) block, sinus bradycardia, malignant AV node reentrant tachycardia syndrome;
• •Secondary hypertension related to suspected or confirmed renal artery stenosis or adrenal gland disorders;
• •Poor glycemic control (HbA1c \> 12%);
• •Orthostatic hypotension (a decrease in blood pressure of \>20/10 mmHg within 3 minutes of standing from a sitting position);
• •Women who are pregnant or breastfeeding at the time of enrollment, or not employing contraception of reproductive age;
• •NYHA (New York Heart Association) Class III-IV congestive heart failure at the time of enrollment;
• •History of myocardial infarction, unstable angina, acute heart failure, stroke, transient ischemic attack (TIA), or cerebral hemorrhage within the 12 weeks prior to enrollment;
• •Underwent coronary revascularization (Percutaneous Coronary Intervention \[PCI\] or Coronary Artery Bypass Grafting \[CABG\]), or valve repair/replacement within the 12 weeks prior to enrollment, or planned to undergo any of the aforementioned surgical procedures after randomization;
• •Any other serious diseases outside the renal and cardiovascular domains, including but not limited to malignancies, with an expected survival of less than 2 years based on the investigator's clinical judgment;
• •Presence of active malignancy requiring pharmacological treatment;
• •AST (Aspartate Aminotransferase) or ALT (Alanine Aminotransferase) levels \>3 times the upper limit of normal (ULN);
• •Total bilirubin \>2 times ULN. Patients with Gilbert's syndrome who exhibit isolated bilirubin elevation do not need to be excluded;