Impact of Chronic Cough on Activities of Daily Living and Response to Acute High-intensity Exercise

Exclusion Criteria

• •Smokers or individuals who gave up smoking within 12 months
• •Smoking history \>20 pack-years
• •Long-COVID or post-COVID syndrome (defined as symptoms lasting over 12-weeks in duration)
• •Recent exacerbation of cough within 4 weeks of inclusion
• •Respiratory tract infection within 4 weeks of inclusion
• •Currently taking any of the following medications:
• •* ACE inhibitors and within 3 months of inclusion
• •* Antitussives (opioids, pregabalin, gabapentin, amitriptyline, nortriptyline, or over the-counter medications) within 2 weeks of inclusion
• •* Medical treatments for gastro-oesophageal reflux disease (GORD), eosinophilic bronchitis or other cough related conditions, initiated or changed (i.e., not in a stable regimen) for 4 weeks prior to inclusion
• •Medical history of asthma or exercise-induced bronchoconstriction (EIB), COPD, or chronic bronchitis in the judgement of the investigator
• •Medical conditions/history or other circumstances which, in the judgement of the investigators, could increase the risk of adverse events or bias the study results