CHiR Therapy for Elderly DLBCL Intolerant to Chemo

Inclusion Criteria

• •1. Age ≥ 70 years;
• •2. ECOG score of 0-3;
• •3. Rated as unfit or frail on the simplified geriatric assessment (sGA);
• •4. Histologically confirmed CD20-positive diffuse large B-cell lymphoma (diagnostic criteria according to WHO 2016), excluding transformed type 2 DLBCL;
• •5. Immunohistochemically confirmed positive expression of MYC and BCL2 (MYC ≥ 40%, BCL2 ≥ 50% by immunohistochemistry);
• •6. Previously untreated patients;
• •7. Cardiac, hepatic, and renal function: creatinine \< 2 times the upper limit of normal (ULN); ALT (alanine aminotransferase)/AST (aspartate aminotransferase) \< 2.5 ULN; total bilirubin \< 2 ULN;
• •8. At least one measurable lesion;
• •9. Unable to tolerate standard CHOP regimen chemotherapy or unwilling to receive chemotherapy;