Research Investigating Drug Effects-2 (RiDE-2)

Exclusion Criteria

• •positive urine drug screen (UDS; except for THC) and/or positive saliva THC test
• •contraindication for fMRI BOLD study (e.g., metal implants)
• •severe mental illness (e.g., psychosis, mania, lifetime moderate-to-severe SUD (including moderate-to-severe CUD))
• •heavy nicotine use in the past month (\>20 cigarettes per week or electronic nicotine delivery system (ENDS) use equivalent
• •night shift work
• •females who are currently pregnant confirmed by urine pregnancy test, are planning pregnancy, or are lactating
• •unwilling/unable to sign informed consent document
• •current or past allergic or adverse reaction or known sensitivity to cannabinoid-like substances (Dronabinol/Marijuana/Cannabis/THC, cannabinoid oil, sesame oil, gelatin, glycerin, and titanium dioxide)
• •physical or neurological diagnoses (e.g., cancer, diabetes, seizure disorder, Parkinson's, Multiple Sclerosis, loss of consciousness \>10 min., etc.) that in the opinion of the Study Physician and Investigators could increase safety risks or influence the findings
• •currently taking any medication that could interact with a single dose of Δ9-THC