Sintilimab Plus Rituximab Followed by R-CHOP Regimen in Untreated PMBL

Exclusion Criteria

• •1. Primary central nervous system lymphoma or secondary central nervous system involvement.
• •2. previous treatment with immune checkpoint inhibitors (PD-1, PD-L1, CTLA-4, etc.).
• •3 History of severe allergic or allergic reactions to humanized or murine monoclonal antibodies.
• •4\. Patients with active autoimmune diseases that require systemic treatment within the past two years; patients with autoimmune diseases that do not require systemic treatment within the past two years may be enrolled.
• •5\. Subjects requiring systemic glucocorticoid therapy or other immunosuppressive therapy for a condition within 14 days prior to starting study treatment \[subjects are allowed to be treated with topical, ocular, intra-articular, intranasal, and inhaled glucocorticoids (with minimal systemic absorption); short-term (≤ 7 days) glucocorticoid prophylaxis (e.g., contrast agent allergy) or for the treatment of non-autoimmune diseases (e.g., delayed hypersensitivity due to contact allergens) is allowed\]. Low dose steroid debulking therapy for large tumor burden may be excluded (prednisone 30 mg bid × 5 days or equivalent doses of other steroids are allowed).
• •6\. Other malignancies within the past 5 years, except for radically treated cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma, breast carcinoma in situ, and cervical carcinoma in situ.
• •7\. Systemic anti-tumor therapy within 28 days before starting study treatment, including chemotherapy, immunotherapy, biological therapy (tumor vaccine, cytokines, or growth factors to control cancer), etc.
• •8\. Major surgery within 28 days or radiation therapy within 90 days prior to starting study treatment.
• •9\. Anti-cancer Chinese herbal medicine or Chinese patent medicine within 7 days prior to starting study treatment.
• •10\. Administration of live vaccines (except attenuated influenza vaccines) within 28 days prior to starting study treatment.
• •11\. Patients with known history of human immunodeficiency virus infection and/or acquired immunodeficiency syndrome.
• •12\. Patients with active chronic hepatitis B or active hepatitis C. Patients who are positive for hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV) antibodies at screening must be further tested for hepatitis B virus (HBV) DNA titer (not more than 2500 copies/mL or 1000 IU/mL) and HCV RNA (not more than the lower limit of detection of the assay).
• •13\. Any active infection requiring systemic anti-infective therapy within 14 days prior to starting study treatment.
• •14\. Pregnant or lactating women. 15. Have uncontrolled concomitant disease. 19. Patients with a previous history of mental illness; those who are incapacitated or have limited behavioral ability.