Hypofractionated Radiotherapy

Exclusion Criteria

• •1. Received any previous systemic antitumor therapy against the target lesion;
• •2. Prior radiation therapy to the head;
• •3. Had a history of low-grade glioma and the current tumor transitioned to glioblastoma;
• •4. The patient had glioma in other parts in the past, and now had metastasis, and the metastatic site was glioblastoma.
• •5. Subjects were unable to undergo MRI examination or unable to undergo enhanced MRI examination.
• •6. Patients who received bevacizumab or iodine internal radiation within one month before enrollment;
• •7. Participants who participated in other clinical trials within 1 month before enrollment;
• •8. Subjects with severe trauma or severe infection within 1 month before enrollment, including but not limited to infectious complications requiring hospitalization, bacteremia, severe pneumonia, etc.
• •9. Severe cardiovascular disease: grade Ⅱ or above myocardial ischemia or myocardial infarction, uncontrolled arrhythmia (QTc interval ≥ 450 ms in men and ≥ 470 ms in women); Patients with grade ⅲ-ⅳ cardiac dysfunction (according to the New York Heart Association NYHA classification, see Appendix 3) or left ventricular ejection fraction (LVEF) less than 50% on echocardiography;
• •10. Subjects underwent major surgery (excluding glioma surgery) within 4 weeks before enrollment;
• •11. The subjects had a history of psychotropic drug abuse or drug use;
• •12. Patients with other malignant tumors within 5 years before enrollment (if cured) were excluded;
• •13. Human immunodeficiency virus (HIV) infection or known acquired immunodeficiency syndrome (AIDS), active hepatitis B (HBV DNA≥500 IU/ml), hepatitis C (hepatitis C antibody positive and HCV-RNA higher than the detection limit of the analytical method) or co-infection with hepatitis B and C;
• •14. Subjects were allergic to temozolomide or could not receive temozolomide treatment for other reasons;
• •15. The results of blood pregnancy test of female subjects during non-lactation period and within 7 days before the first study treatment were positive. The subject (male or female) declined to commit to using at least one acceptable contraceptive method (i.e., using an intrauterine device (IUD), condom, any form of hormonal contraceptive, or abstinence, etc.) for the entire duration of the study and for 3 months after the last study treatment;
• •16. Other conditions that increase the risk associated with participating in the study or the study drug and, in the investigator's judgment, may make the subject ineligible for the study;
• •17. The investigator determined that he was not fit to participate in the study.