Upfront Surgery Vs Induction Chemotherapy Followed By Surgery In Oral Cancers:

Inclusion Criteria

• •Newly diagnosed, treatment naïve, biopsy or cytology proven OSCC
• •Clinical Stage cT1-4a, cN2-N3\*\*, M0- as per UICC 2018
• •No evidence of distant metastases on chest x-ray and/or CT Thorax
• •ECOG PS 0-2
• •No contraindication to Cisplatin or radiotherapy\*\*\*
• •Patients eligible for definitive curative intent treatment after discussion in multidisciplinary tumour board
• •Adequate organ function at time of participation, defined as Haematological: Haemoglobin \> 9gm/dl, ANC ≥ 1500/cmm3, Platelet ≥100000/cmm3 Liver Function test: Bilirubin ≤2 x upper limit normal (ULN), AST/ALT/ ALP ≤ 2.5 x ULN Renal Function test: Creatinine ≤ 1.5 ULN, Creatinine Clearance ≥60 ml/min.