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Omega-3 Fatty Acids and Subconcussive Head Impacts | Clinical Trials | Clareo Health

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RECRUITINGNANCT06736925

Omega-3 Fatty Acids and Subconcussive Head Impacts

The purpose of the proposed double-blind, randomized placebo-controlled trial is to understand how supplementation with fish oil \[docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)\] promote ...

Lead sponsor: Indiana University•1 U.S. locations•View source on ClinicalTrials.gov

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Contacts

Kei Kawata

CONTACT

812-855-5244 [email protected]

Sponsors

Lead Sponsor

Indiana University

Collaborators

National Institute of Neurological Disorders and Stroke (NINDS)

The purpose of the proposed study is to determine whether, and to what extent, supplementation with omega-3 fatty acids \[docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)\] can maintain or promote neural wellbeing against repetitive subconcussive head impacts. This study will also characterize what aspects of brain cellular and physiologic resiliencies are enhanced by supplementation in adult soccer players (aged 18-30 years old). A sub-cohort of participants who meet criteria for ADHD diagnosis will be part of exploratory analysises.

Age

18 - 30 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Between age 18-30
•Current or former soccer player
•At least 5 years of soccer heading experience
•Have internet access
•Willing to commit to avoid any sport activity that purposefully uses one's head to maneuver during the study period (American football, ice-hockey, rugby, wrestling, and soccer heading).

Exclusion Criteria

•Any head or neck injury within 6 months before the study
•Implanted metal/magnetic devices (e.g., orthodontic braces
•Diagnosed autonomic or cardiovascular diseases (e.g., hypertension)
•Consuming oily fish (2 servings or more/month: salmon, bluefin, swordfish, anchovies)
•Allergy to fish or shellfish
•Consuming omega-3 FA supplements including plant-based (e.g., flaxseed) in the past 3 months.
•Pregnancy

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 5, 2025Terms

Trial snapshot

StatusRECRUITING

PhaseNA

Enrollment208

Start dateFeb 2025

Last updatedMar 5, 2025

Condition

Subconcussive Head Impact Omega-3 Fatty Acids

Locations shown

Indiana University School of Public Health

Bloomington, Indiana

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 5, 2025Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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