Adult recipients (\>18y), listed for liver transplantation with documented HCC (Liver Imaging Reporting and Data System (LIRADS) 5 lesion in magnetic resonance imaging or computer tomography of the liver or biopsy proven),
within up to seven criteria, i.e. HCC with seven as the sum of the diameter of the largest tumour (in cm) and the number of tumours at the time point of liver transplantation,
written informed consent for the trial. This also includes patients beyond the up to seven criteria after successful downsizing of the HCC
You may not be if
Donation after circulatory death (DCD) liver grafts
Combined liver transplants
Partial liver transplants
Combined or mixed hepatocellular cholangiocarcinoma (cHCC-CCC) or pure cholangiocarcinoma or other malignancies in histopathology of the liver explant
Systemic antitumoural medical treatment with checkpoint inhibitors or multikinase inhibitors
Post-transplant treatment with mTOR inhibitors
Acute and unexpected medical contraindications
Pregnancy
Cold storage time of \> 10 hours (both study arms)
