The Use of 5-ALA in Paediatric Patients With High Grade Brain Tumours

Inclusion Criteria

• •Magnetic Resonance Imaging confirmation of diagnosis consistent with either: primary presentation of high grade brain tumour OR patient relapsing with previously confirmed ependymoma or high-grade glial tumour
• •Tumours will be either intrinsic supratentorial or infratentorial / posterior fossa, non-brainstem, tumours
• •Patient is appropriate for maximal safe resection of tumour, based on Investigator and Multidisciplinary Team judgement
• •3 - 18 years inclusive
• •Adequate liver and kidney function
• •* creatinine - less than one and a half times the upper limit of normal.
• •* haemoglobin above the lower limit of normal
• •* Alanine transferase or Aspartate transferase less than twice the upper limit of normal (if both performed, then both results must be lower than twice the upper limit of normal
• •* bilirubin lower than one and a half times the upper limit of normal
• •Normal Coagulation profile
• •o Prothombin Time, Activated Partial Prothombin Time and Thrombin Time all within normal limits
• •Urine porphyrin - Test to be completed and sent for analysis
• •Blood pressure lower than or equal to the upper limit of normal
• •Negative pregnancy test in women of childbearing potential\*
• •Informed Consent \*A positive pregnancy test that is suspected to be due to the location of the tumour is to be queried with the TMG prior to registration of the patient