Indocyanine Green Fluoroscopy and SPY Angiography for the Assessment of Lymphatic Structure in Breast Cancer Patients at Risk for Breast Cancer-Related Lymphedema

PRIMARY OBJECTIVE: I. Assess the change in lymphatic architecture resulting from placement of an IV line and fluid administration in patients at risk for BCRL. SECONDARY OBJECTIVES: I. Identify changes in presence/severity of lymphedema based on: Ia. SOZO Digital Health Platform scale; Ib. Patient self-reported outcomes; Ic. Arm circumference. II. Assess association between SOZO scale, MD Anderson Cancer Center (MDACC) lymphedema score (LS), and patient-reported outcomes. EXPLORATORY OBJECTIVES: I. Observe changes in mapping of superficial lymphatics that are responsible for the upper extremity arm with use of ICG dye and SPY angiography. II. Identify risk factors associated with higher rates of lymphedema after IV line/fluid administration. OUTLINE: Patients receive ICG dye subcutaneously (SC) and receive fluids IV over one hour and undergo SPY imaging and lymphedema assessment on day 1. Patients also receive ICG dye and undergo imaging and lymphedema assessments again at 1, 3, 6, and 12 months on study.