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RECRUITINGNCT06650306

The Impact of Soft Contact Lenses on the Corneal Neuromediators and Optical Quality in High Myopia Prior to SMILE

To investigate the influence of Neuromediators expression in corneal stromal lenticules and corneal injury repair after small incision extraction

Lead sponsor: yuhao shao•1 locations•View source on ClinicalTrials.gov

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Contacts

min Li, Dr

CONTACT

+86 18817367841 [email protected]

Yuhao Shao, MD

CONTACT

Sponsors

Lead Sponsor

yuhao shao

This study included 160 eyes from high myopia patients who underwent Small Incision Lenticule Extraction. Patients were devided into three groups based on duration of wearing SCLs: \> 10 years group, ≤ 10 years group, and NW group (not SCLs). Corneal higher-order aberrations and densitometry were evaluated using a Pentacam system. Neuromediator levels in corneal stromal lenticules were analyzed using ELISA and immunofluorescence

Age

18 - 45 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•age ≥ 18 years with stable refraction for at least two years;
•spherical equivalent (SE) \< -6.00 D;
•corrected distance visual acuity of 20/20 or better;
•no history of using rigid gas permeable lenses or orthokeratology (OK) lenses prior to examination

Exclusion Criteria

•\- a history of moderate to severe dry eye as well as any ocular or systemic disease that would contraindicate laser refractive surgery.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: October 21, 2024Terms

Trial snapshot

StatusRECRUITING

Phase—

Enrollment80

Start dateOct 2024

Last updatedOct 21, 2024

Condition

Contact Lens Complication

Locations shown

Shanghai Tenth People's Hospital

Shanghai, Shanghai Municipality

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 21, 2024Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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