Combined Guanfacine and Mindfulness Meditation as an Adjunct to Buprenorphine Maintenance in Opioid Use Disorder

Exclusion Criteria

• •Current SCID V criteria for a moderate to severe substance use disorder other than opioids or nicotine (although mild use will be permitted)
• •Use of medications in the last 6 months that may affect cerebral function with the exception of BUP and individuals stabilized on SSRIs
• •psychotic or severely psychiatrically disabled (i.e. suicidal, current mania)
• •hypotensive individuals with sitting blood pressure below 100/50 mmHG
• •Women who are pregnant, nursing or refuse to use a reliable form of birth control
• •EKG evidence at baseline screening of any clinically significant conduction abnormalities (Bazett's QTc of \>450 msec for men and QTc\>470 msec for women)
• •R33 phase will additionally include failure to satisfy fMRI safety protocols.