Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Age ≥ 18 years
New clinical and radiological suspected diagnosis of IDH-wildtype glioblastoma or grade IV IDH-mutant astrocytoma
Visible FET PET uptake in the tumor as assessed by the nuclear physician
Indication for a surgical resection and adjuvant treatment according to the neuro oncology multidisciplinary meeting
Eligible for a supramarginal resection according to two neurosurgeons in consensus
Karnofsky Performance Score (KPS) ≥ 70.

Previous brain surgery or cranial radiotherapy
No significant other brain pathology, in the opinion of the PI or designee, such as multiple sclerosis, neurodegenerative disease, stroke
Tumor located infratentorially or in the spinal cord
Lack of adequate social or family support needed for adherence to the further postoperative therapeutic regimen
Pregnancy

Extensive Resection of Malignant Brain Tumors Using Advanced Imaging Techniques