Donafenib as Adjuvant Therapy Following Ablation for Recurrent HCC

Inclusion Criteria

• •1. were aged 18-75 years;
• •2. had recurrent HCC (RHCC) diagnosed by imaging studies, the first or the second RHCC;
• •3. RHCC met the Milan criteria, namely single RHCC lesion less than 5 cm in diameter or no more than 3 tumors (each ≤3 cm in diameter);
• •4. the early RHCC (recurrent time \<1 year)
• •5. patients were unwilling to undergo repeat hepatectomy or liver transplantation;
• •6. had well-preserved liver function, i.e., Child-Pugh class A or B, and prolonged prothrombin time≤5 s;
• •7. patients had an Eastern Cooperative Oncology Group performance status score ≤1.
• •8. Ability to understand the protocol and to agree to and sign a written informed consent document.