Effect of Cannabis on Cigarette Use Behavior

Exclusion Criteria

• •1. Report current intention to reduce or quit cannabis or tobacco use within the next 30 days
• •2. Meet Diagnostic and Statistical Manual (DSM-5) criteria for a substance use disorder other than alcohol, cannabis, or nicotine
• •3. Test positive for illicit drugs other than cannabis and tobacco
• •4. Positive breath alcohol test at study admission
• •5. Have a current physical or mental illness judged by the study team to negatively impact participant safety or scientific integrity
• •6. Have a lifetime history of suicidal behavior (i.e. past suicide attempt), or current suicidal behavior or ideation as assessed by the Columbia Suicide Severity Rating Scale (C-SSRS)
• •7. Are currently pregnant, planning to become pregnant in the next three months or are currently breastfeeding
• •8. Have a history of clinically significant cardiac arrhythmias or vasospastic disease (e.g., Prinzmetal's angina)
• •9. Are currently enrolled in another clinical trial or have received any drug as part of a research study within 30 days of study participation.