Effectiveness of Entresto (Sacubitril/Valsartan) in Japanese Patients With Hypertension

Exclusion Criteria

• •1. Women with a record of pregnancy-related diagnoses, drugs, or medical procedures before or after the index date, or a record of delivery- or abortion-related diagnoses, drugs, or medical procedures after the index date.
• •2. Prescription of concomitant angiotensin-converting enzyme inhibitor (ACEi); Anatomical Therapeutic Chemical (ATC) code: C09A on, after, or in the 2 days before the index date.
• •3. Patients diagnosed with angioedema: ICD-10: D84.1 under prescription of ACEi or angiotensin receptor blocker (ARB); ATC code: C09C.
• •4. Patients diagnosed with diabetes and under treatment with aliskiren fumarate on the index date.
• •5. Patients with severe impaired liver functions with Child-Pugh classification C.