Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction

Exclusion Criteria

• •Significant trauma to a weight-bearing joint within 12 months prior to study initiation (excluding the ACL injury)
• •Previous surgeries on the study knee (except for the ACL reconstruction)
• •Signs of knee OA as defined by the OARSI-Joint Space Narrowing (JSN) Score of two or more (standing AP x-ray)
• •Physical activity level: Tegner activity score before injury of 0-2 (very low activity) or 8-10 (very high activity)
• •Body mass index ≥ 30 kg/m2;
• •Inflammatory arthropathies;
• •Immunosuppression due to illness or medication;
• •Sepsis or hemostasis disorders;
• •Severe uncontrolled inflammatory disease or autoimmune disease (e.g., ulcerative colitis, Crohn's disease, etc.);
• •Having malignancy and undergoing treatment including chemotherapy, radiotherapy, or immunotherapy;
• •Contraindications for MRI, including pacemakers, defibrillators, metal implants, pregnancy, sensorineural hearing loss above 30 dB, tinnitus and claustrophobia
• •Unable to freely give their informed consent (e.g., individuals under legal guardianship).
• •Currently enrolled in or has not yet completed a period of at least 5 times as the half-life time of the drug used in the previous trial since ending other investigational device or drug trial(s)
• •Patients who are dependent on the sponsor, investigator, or study site;
• •Pregnant or breast-feeding women or women of childbearing potential not protected by an effective contraceptive method of birth control (defined as pearl index \< 1);
• •Any form of substance abuse, psychiatric disorder, or other condition that, in the opinion of the Investigator, may invalidate communication with the Investigator and/or designated study personnel;
• •Patients who are committed to an institution by virtue of an order issued by either the judicial or the administrative authorities;