Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Sun Yat-sen University
With
Tianjin Medical University Cancer Institute and Hospital
RenJi Hospital
Sixth Affiliated Hospital, Sun Yat-sen University
First Affiliated Hospital of Jinan University
The First Affiliated Hospital with Nanjing Medical University
Shanghai Changzheng Hospital
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Suining Central Hospital
The Affiliated Hospital of Xuzhou Medical University
The General Hospital of Eastern Theater Command
Fujian Medical University Union Hospital
First Affiliated Hospital of Kunming Medical University
Fujian Provincial Hospital
Tianjin Chest Hospital
Sichuan Cancer Hospital and Research Institute
Tang-Du Hospital
Shandong Provincial Hospital
Gansu Provincial Hospital
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan TongJi Hospital
The Affiliated Hospital of Qingdao University
West China Hospital
Jiangsu Cancer Institute & Hospital
Dongguan People's Hospital
First People's Hospital of Foshan
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Age from 18 to 80 years old;
2. The first clinical diagnosis before surgery was non-small cell lung cancer, including adenocarcinoma, squamous cell carcinoma, large cell carcinoma, and other unknown types;
3. Clinical stage T1-2N0-1 (cI-II): Maximum diameter of tumor \<= 5 cm and short diameter of mediastinal lymph node \<= 1cm in thin layer computed tomography (CT);
4. The patient's physical condition is able to tolerate lobectomy: (1) Goldman index 0-1; (2) Predicted forced expiratory volume in 1s (FEV1) \>= 40% and diffusing capacity of the lung for carbon monoxide (DLCO) \>= 40%; (3) Total bilirubin \<= 1.5 upper limit of normal; (4) Alanine aminotransferase (ALT)/Aspartate aminotransferase (AST) \<= 2.5 upper limit of normal; (5) Creatinine \<= 1.25 upper limit of normal and creatinine clearance rate (CCr) \>= 60 ml/min;
5. Performance status of Eastern Cooperative Oncology Group (ECOG) = 0-1;
6. All relevant examinations were completed within 28 days before the operation;
7. Patients who understand this study and have signed an approved Informed Consent.
You may not be if
1. Patients who have undergone anti-tumor therapy (radiotherapy, chemotherapy, targeted therapy, immunotherapy) before surgery;
2. Patients with previous medical history of other malignant tumors or combined with second primary cancer at the time of enrollment;
3. Patients who meet all of the following criteria are eligible for sublobar resection (segment/wedge resection): (1) Ground glass opacity (GGO) with a solid component \<= 50%; (2) The largest diameter of nodule is \<= 2 cm; (3) The nodule is located in the outer third of the lung field;
4. Patients with preoperative diagnosis of pure GGO;
5. Patients with previous medical history of unilateral thoracotomy;
6. Women who are pregnant or breastfeeding;
7. Patients with active bacterial or fungal infection that is difficult to control;
8. Patients with serious psychosis;
9. Patients with a history of severe heart disease, heart failure, myocardial infarction or angina pectoris in the past 6 months.
Clareo Health | Lobectomy-First vs. Lymphadenectomy-First for Operable NSCLC (LOFTY)
