\*\*AIM1.\*\*
1. \*\*Identification\*\* of genes and biological pathways associated with IPMN malignant transformation. The investigators aim to explore the molecular dynamics of tumor progression, focusing on cellular heterogeneity and phenotypic transitions.
2. \*\*Characterization of the microenvironment\*\* to understand its role in IPMN progression. The investigators will collect archival samples from 240 patients across four centers.
3. \*\*Identification and validation in plasma\*\* of selected patients of differentially expressed markers in indolent IPMN, invasive IPMN, and PDAC.
\*\*AIM2.\*\* The investigators will develop knowledge-based tools for diagnosing and treating IPMN and at-risk populations.
\*\*AIM3.\*\* The investigators will validate the role of key genes in IPMN carcinogenesis using in vitro study models.
