Preliminary Evaluation of the Safety and Tolerability of SPOT-mRNA01 Subcutaneously Administered in Healthy Subjects

Exclusion Criteria

• •1. Any transient or chronic skin condition, disorder, or infection within 20 cm of the target areas before treatment that, in the opinion of the investigator, may confound study results.
• •2. History of laser treatment or chemical peels or any cosmetic anti-aging treatments to the target areas within six months of the study treatment.
• •3. History of surgical procedures to target areas, including removal of benign or malignant skin cancers that, in the opinion of the investigator, may confound study results.
• •4. Participant with a history of heavy smoking, alcohol or drug abuse or steroid treatment.
• •5. Pregnant or breast-feeding females.
• •6. History of anaphylaxis or allergic reactions to any constituent of the study product and/or local anesthetics, and/or history of severe abnormal drug reaction.
• •7. Those who have participated in clinical trials of other investigational drugs within 3 months before the study treatment.
• •8. Those who are not suitable for subcutaneous injection and biopsy.
• •9. Any condition that the investigator or primary physician believes may not be appropriate for participating the study.