A Study to Test Whether BI 456906 (Survodutide) Influences the Amount of Bupropion, Caffeine and Midazolam in the Blood in People With Overweight or Obesity

Exclusion Criteria

• •1. Any finding in the medical examination (including BP, PR or ECG) deviating from normal and assessed as clinically relevant by the investigator.
• •2. Repeated measurement of systolic blood pressure outside the range of 90 to 140 millimetre of mercury (mmHg), diastolic blood pressure outside the range of 50 to 90 mmHg, or pulse rate outside the range of 50 to 90 beats per minute (bpm)
• •3. Any laboratory value outside the reference range that the investigator considers to be of clinical relevance and in particular:
• •* Alanine aminotransferase (ALT) above upper limit of normal (ULN) + 20%,
• •* Aspartate aminotransferase (AST) above ULN + 20%,
• •* Gamma-Glutamyl-Transferase (GGT) above ULN + 20%,
• •* Lipase or amylase above ULN + 20%,
• •* Estimated glomerular filtration rate (eGFR) \< 80 mL/min/1.73 m².
• •4. Any evidence of a concomitant disease assessed as clinically relevant by the investigator