Non-invasive Electrical Spinal Cord Stimulation To Restore Upper Extremity Function in Multiple Sclerosis

Exclusion Criteria

• •1. Relapse within the past 6 months (given that natural recovery from relapse could skew results)
• •2. Active implanted stimulator or baclofen pump
• •3. Upper extremity botox injection within the past 6 months
• •4. Unstable dalfampridine usage during study duration (which may interfere with functional outcomes)
• •5. Coexisting neurological condition that could interfere with interpretation of testing results (hx of stroke, traumatic brain injury, epilepsy/seizure, ALS, spinal cord injury, central nervous system vasculitis, intracranial tumor, intracranial aneurysm, cervical myelopathy/radiculopathy or peripheral neuropathy (diabetic polyneuropathy, entrapment neuropathy), etc.)
• •6. History of major active psychiatric illness that could interfere with treatment, such as severe depression, alcohol/drug abuse, or dementia
• •7. Serious comorbidities (e.g., cardiac arrhythmia, uncontrolled hypertension, respiratory disease, cancer, renal failure, chronic infectious disease, rheumatic disease, frequent UTIs, etc.) that would prevent participation in study activities
• •8. Presence of severe joint contractures in the affected hand and arm that may interfere with study activities or outcome measures
• •9. Severe spasticity, as defined by an Ashworth score of 4 in both sides of the upper limb
• •10. Pregnant and/or breastfeeding
• •11. Lack of ability to fully comprehend, cooperate, and/or safely perform study procedures in the investigator's opinion/judgment
• •12. Inability to give consent