Iodine Supplementation in Graves' Hyperthyroidism

Exclusion Criteria

• •1. thyroid enlargement of grade 3;
• •2. serum TRAb is measured above 40IU/L;
• •3. moderate or severe thyroid-associated eye diseases;
• •4. hepatic disease history including chronic active hepatitis, severe hepatic dysfunction, liver cirrhosis, etc., and serum transaminase level is 3 times higher than the upper normal limit and/or total bilirubin level is higher than 34.2μmol/L with hepatic protective drugs;
• •5. history of moderate-to-severe or end-stage renal disease: eGFR\<60mL/min/1.73m2 with simplified MDRD formula;
• •6. serum WBC\<3.0×109／L or neutrophil count\<1.5×109／L;
• •7. history of severe cardiocerebrovascular disease, digestive disease, hematopoietic system disease, other autoimmune diseases in addition to Graves' hyperthyroidism, tumors, psychosis, etc.;
• •8. blood pressure\>180/100mmHg with regular antihypertensive drugs treatment;
• •9. severe comorbidities and complications of hyperthyroidism with ATDs treatment;
• •10. history of multiple drug allergies;
• •11. a family planning plan in 3 years.