Beta-blOckers discoNtinuation in Patients Presenting Heart FaIlure With REcovered Left Ventricular Ejection Fraction

Exclusion Criteria

• •1. Atrial, supra-ventricular, or ventricular arrhythmias, in the last 12 months and/or requiring beta-blockers according to investigator.
• •2. Uncontrolled arterial hypertension according to investigator decision.
• •3. Symptomatic angina or evidence of infra-clinic myocardial ischemia requiring beta-blockers according to investigator decision.
• •4. Cardiac resynchronization therapy
• •5. Extra-cardiac conditions requiring beta-blockers (migraine, essential tremor, prevention of bleeding from esophageal varices in patients with liver cirrhosis, adrenergic symptoms of hyperthyroidism…) according to investigator decision.
• •6. History of severe outcomes at beta-blockers interruption: HF relapse, occurrence of arrythmias
• •7. Severe valvulopathy, restrictive, infiltrative or hypertrophic cardiomyopathy, constrictive pericarditis, or acute myocarditis within 3 months prior to inclusion Visit.
• •8. Planned coronary, carotid, or peripheral artery revascularization known at the day of inclusion
• •9. Chronic renal failure with eGFR \<20mL/Min per 1.73m² (CKD-Epi) at inclusion
• •10. Hepatic insufficiency classified as Child-Pugh B or C at the inclusion Visit.
• •11. Any past solid organ transplantation or planned organ transplantation within 12 months
• •12. Any condition other than HF that could limit survival to less than one year
• •13. Pregnancy or breastfeeding women or women of childbearing potential without adequate contraceptive method
• •14. Current participation in another interventional trial.
• •15. Patient under legal protection (protection of the court, or in curatorship or guardianship).
• •16. Any disorder, unwillingness or inability, which in investigator's opinion, might jeopardise the patient's safety or compliance with the protocol