Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

Inclusion Criteria

• •Patients with breast cancer or NSCLC malignancies with leptomeningeal metastases established radiographically and/or through CSF cytology
• •Patients who are candidates for radiation therapy for the treatment of leptomeningeal metastases
• •Patients ≥ 18 years old
• •Karnofsky performance status (KPS) ≥ 60 or Eastern Cooperative Oncology Group (ECOG) ≥ 2
• •The patient is able to provide informed consent
• •Hemoglobin \> 8 g/dL
• •Absolute neutrophil count \> 1,000/mm
• •Platelet count \> 100,000/mm
• •Participants born female at birth must either be of non-reproductive potential (i.e. post-menopausal by history \[≥ 60 years old, or with no menses for \> 1 year without an alternative medical cause\], OR history of hysterectomy, OR history of bilateral tubal ligation, OR history of bilateral oophorectomy) or must have a negative serum /urine pregnancy test within 3 weeks prior to starting radiation therapy (RT)
• •Patients with reproductive potential must agree to practice two highly effective contraceptive methods