Effectiveness and Safety Comparison of Lunaphil Ultra (Hyaluronic Acid, by Espad Pharmed Co.) Versus Juvederm Ultra 4® (Hyaluronic Acid, by Allergan Co.) in Nasolabial Folds (NLFs) Management

Exclusion Criteria

• •History of bleeding disorders or participants receiving or recently exposed (≤ 3 weeks) to continuous treatment with thrombolytics, anticoagulants, platelet inhibitors, or NSAIDs
• •Acute herpetic eruption
• •Known susceptibility to keloid formation, hypertrophic scarring or clinically significant skin pigmentation disorders
• •Known sensitivity to local anesthetics of the amide type (such as lidocaine), history of hypersensitivity to gram-positive bacterial proteins, history of multiple severe allergies, history of anaphylactic shock
• •Known hypersensitivity to any component of the study products or excipients (like hyaluronic acid)
• •History of receiving immune therapy or a history of autoimmune disease
• •History of active chronic debilitating systemic disease
• •History of connective tissue disease, history of malignancy (except for non-melanoma skin cancer) within the last 5 years
• •Clinically significant active dermatologic disorders within the last 6 months
• •Use of oral retinoids, over-the-counter (OTC) or prescription antiwrinkle treatments, microdermabrasion, or chemical peels in the NLF area within the last 4 weeks or intention to use them during the study
• •Any prior cosmetic procedure or tissue augmentation at the NLF injection site within 1 year before study entry (or intent to undergo such a procedure during the study)
• •Pregnancy or breastfeeding