Lead Sponsor

Mansoura University

Age

30 - 50 years

Sex

ALL

Healthy Volunteers

No

•\- Patients having obstructive sleep apnea syndrome (OSAS) as determined by polysomnography with mild to moderate apnea/hypopnea index ranging from 5 to 30 events per hour of sleep. ( As 5-15 events per hour is considered mild condition, 16-30 is considered moderate).(1)
•2- Adequate nasal air flow capacity as determined by qualified otolaryngologist.

•patients having Central sleep apnea events as determined by the polysomnography.
•2- patients having cardiovascular disease. 3- History of alcohol, narcotic or psychoactive medications. 4- Serious nasal passage obstructions or allergies. 5- Previous history of treatment with any type of obstructive sleep apnea oral appliances.
•6- Obese patients with BMI more than 30. 7- Missing more than five teeth (excluding third molar). 8- Allergy to acrylic resin.