Safety and Adequacy of Trans-jugular Liver Biopsy in Patients With Liver Disease: SAFE-TJLB Study

Hypothesis: Trans-jugular liver biopsy is safe, gives adequate sample for pathological examination in patients with liver disease. Aim of study: To evaluate safety and adequacy of trans-jugular liver biopsy in patient with liver disease. Primary objective: 1. Adequacy of trans-jugular liver biopsy 2. Safety of trans-jugular liver biopsy Secondary objective: 1. Indications of liver biopsy 2. Procedural time (in and out of catheter) 3. Number of passes 4. Failure rate 5. Day care time 6. VAS: pain (Abdomen and Neck, pre and post procedure) 7. Complications- arrythmia, hematoma 8. Time of Fluro exposure Patients and methods Study Design A prospective, observational cohort study will be conducted in patients with suspected or known liver disease between November 2023 to May 2024 at the Institute of Liver and Biliary Sciences (ILBS), New Delhi. Clinical protocol An informed consent was taken from patients with liver disease undergoing liver biopsy as per clinical indication. The following demographic data was recorded at inclusion: Age, gender, co-morbidities, type, and etiology of liver disease. Laboratory parameters include complete blood count, liver function tests, kidney function tests, INR. Severity of liver disease (MELD score, CTP score, AARC score).