Single macroscopic tumor focus with the appearance of glioblastoma multiforme on MRI with contrast - contrast-enhancing lesion, completely or with central necrosis, with surrounding edema.
No history of cancer in other organs. No suspicious lesions on X-ray of the chest and abdomen (CT with contrast).
No clinical suspicion of brain abscess - no meningeal symptoms, signs of neuroinfection, fever, elevated inflammatory parameters.
Primary tumor, without neurosurgical, radiotherapy or oncology intervention. Prior tumor biopsy is allowed.
Tumor eligible for surgical treatment - craniotomy and tumor resection.
Age ≥ 18 years but \< 70 years old.
Quality of life assessment: KPS ≥ 70.
Informed patient consent to the study and proposed treatment.
No allergy to contrast agents used in PET and MRI.
No medical contraindications to neurosurgery - craniotomy and resection.
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Multifocal brain tumor.
Recurrence of glioblastoma multiforme.
Clinical or radiological suspicion of brain metastasis or brain abscess.
Postoperative histopathological diagnosis other than WHO grade IV glioblastoma.
Medical contraindications to any surgery under general anesthesia.
Pregnancy, breastfeeding.
Known allergy to gadolinium contrast or radiopharmaceutical tracing agent.
Clareo Health | Application of FET-PET in Fusion With MRI in the Treatment of Glioblastoma Multiforme [TYR-GLIO]
