Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Hunter Holmes Mcguire Veteran Affairs Medical Center
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Age \>18 years
2. Ability to provide informed written consent
3. Cirrhosis diagnosis
4. Willing to comply with all study procedures and be available for the duration of the study.
5. Ability to take oral medication.
6. Willing to provide study-related samples
7. Meeting the PCL-5 definition of PTSD and have a chart diagnosis of PTSD made by a mental health provider
You may not be if
1. Known SARS-CoV-2 infection in the last 60 days using medical records
2. Subjects identified as, or appearing to, lack consent capacity
3. Alcohol abuse (greater than 14 drinks per week for men and 7 drinks per week for women)
4. Active illicit drug use (marijuana is allowed)
5. Use of investigational drugs, biologics, or devices within 30 days prior to randomization.
6. Individuals who are pregnant, lactating or planning on becoming pregnant during the study
7. Diagnosed inflammatory bowel disease, Crohn's disease, or Celiac disease
8. Unstable psychiatric illness (psychosis)
9. Previous gastrointestinal surgery (colorectal surgery, gastric bypass, intestinal resection)
10. Use of other prebiotics, probiotics (including yogurt containing live probiotics), postbiotics, or other fiber supplements in the last 30 days
11. Systemic antibiotics in the last 30 days
12. Fecal microbiota transplant in the last 30 days
13. Active dysphagia
14. Allergies to any of the ingredients in assigned products
15. Use of anti-diarrheal agents, stool softeners, or immunomodulatory medications in the last 30 days.
16. On treatment for hepatic encephalopathy.
17. Any other factor, condition, or medication not listed above the Investigators believe will affect the response in the gut or the interpretation of results.
Clareo Health | Microbiome Modulation With Prebiotics in PTSD and Cirrhosis
