Lead Sponsor

Pfizer

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Yes

•1. Males 18 to 65 years of age and females of non-childbearing potential;
•2. Body mass index (BMI) of 16 to 32 kg/m2; and a total body weight \>50 kg (110 lb);
•3. Over prior 4 weeks an average of less than 150 minutes of moderate-intensity aerobic physical activity throughout each week, and less than 75 minutes of vigorous-intensity aerobic physical activity throughout each week, or an equivalent combination of moderate- and vigorous-intensity activity.

•1. Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, or allergic disease;
•2. History of human immunodeficiency virus (HIV) infection, hepatitis B or hepatitis C;
•3. Kidney impairment as defined by an estimated glomerular filtration rate (eGFR) \<75 mL/min/1.73 m²;
•4. A positive urine drug test;
•5. Participation in studies of other investigational products (drug or vaccine) at any time during participation in this study.