To Compare the Efficacy and Safety of HRS9531 and Placebo in Subjects With Overweight or Obese

Exclusion Criteria

• •1. Presence of clinically significant lab results at screening visit;
• •2. Uncontrollable hypertension;
• •3. PHQ-9 score ≥15;
• •4. Medical history or illness that affects your weight;
• •5. History of diabetes;
• •6. Acute infection, acute trauma, or medium to large surgery within 1 month prior to screening;
• •7. History of acute cardiovascular and cerebrovascular diseases within 6 months prior to screening;
• •8. Any organ-system malignancies developed within 5 years except for cured local basal cell cancer of the skin、 in-situ cancer of the cervix and in-situ cancer of the prostate;
• •9. Confirmed or suspected depression, bipolar disorder, suicidal tendencies, schizophrenia, or other serious mental illness;
• •10. Known or suspected history of alcohol and/or substance abuse or drug abuse;
• •11. History of acute or chronic hepatitis or other serious liver disease other than alcoholic fatty liver disease.
• •12. Have received or plan to have an organ or bone marrow transplant during the study.
• •13. The presence of any blood disorders that may interfere with HbA1c testing.
• •14. Autoimmune disease is present and systemic glucocorticoid therapy or immunosuppressive therapy is planned during the study.
• •15. Use of drugs or treatments that may have caused significant weight gain or loss within the 3 months prior to screening;
• •16. Weight loss surgery or endoscopic and/or medical device-based weight loss therapy is planned for or during the study period;
• •17. Use of drugs or treatments that may have caused significant weight gain or loss within the 3 months prior to screening;
• •18. Patients with blood donation or blood loss ≥400 mL or receiving blood transfusion within 3 months before screening.
• •19. Surgery is planned during the tria;
• •20. Mentally incapacitated or speech-impaired subjects are unable to fully understand or participate in the test process；
• •21. In the investigator's judgment, there are circumstances (medical, psychological, social, or geographical factors, etc.) that affect subject safety or any other conditions that interfere with the evaluation of the test results.