Clinical Study of Huaier Granule in the Treatment of Unresectable Pancreatic Cancer

Exclusion Criteria

• •Known to be allergic to the components of Huaier granules or to avoid or use Huaier granules with caution (Huaier group).
• •Patients with difficulty swallowing, complete or incomplete gastrointestinal obstruction (excluding those who have undergone gastrointestinal stenting or diversion surgery due to tumor related gastrointestinal obstruction and have a normal diet, can be included in the study normally), active gastrointestinal bleeding, perforation, and other oral medication difficulties.
• •After actively reducing jaundice (including but not limited to bile duct/gallbladder puncture external drainage, nasobiliary duct external drainage, biliary stent internal drainage, biliary intestinal anastomosis internal drainage, etc.), the levels of aspartate aminotransferase, alanine aminotransferase, or total bilirubin are still 2.5 times higher than the upper limit of normal values.
• •History of merging with other malignant tumors.
• •Patients with concomitant myocardial infarction, cerebral infarction, and other thromboembolic diseases requiring surgical treatment.
• •Concomitant severe infection.
• •Child-Pugh C-grade liver function, renal function 2-5 grades (glomerular filtration rate\<90ml/min).
• •Pregnant or lactating women or those planning to conceive.
• •The patient has received other traditional Chinese patent medicines and simple preparations with anti-tumor effect, chemotherapy or physical therapy in the past 4 weeks(including but not limited to compound cantharidin capsules, cinobufotalin capsules, Kangai injection, please refer to the drug instructions for details).
• •Suffering from serious mental illness or other reasons that the researcher deems unsuitable to participate in this study.