Multi-Center Clean Air Randomized Controlled Trial in COPD

Inclusion Criteria

• •To be eligible, subjects must meet all these criteria:
• •1. Age ≥ 40 years.
• •2. Self-report of physician diagnosis of COPD.
• •3. Spirometry confirmed airway obstruction (post-bronchodilator spirometry of forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) \< 0.7) as defined by the Global Initiative for Obstructive Lung Disease (GOLD) criteria (6, 11)
• •4. Tobacco exposure ≥ 10 pack-years. This refers to regular cigarette tobacco consumption.
• •5. Self-reported former smoker of at least 6 months' duration. This does not include e-cigarette use.
• •6. COPD Assessment Test (CAT) score ≥ 10, Modified Medical Research Council dyspnea scale (mMRC) ≥ 2, or history of moderate or severe exacerbation in the past 12 months (as defined by history of receiving a course of systemic corticosteroids or antibiotics for respiratory problems; or visiting an emergency department or being hospitalized for a COPD exacerbation within the past 12 months.)
• •7. Inability to bring air cleaners (about 15 pounds each) into home, either by self, friend, or relative
• •8. Deemed by the study investigator to be unable to complete study protocol, including likely lack of internet connectivity
• •9. Participating in another interventional clinical trial