Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat

This study will image 150 subjects total, as outlined below. Subjects will be asked to participate in magnetic resonance imaging (MRI) and PET imaging procedures as well as behavioral and cognitive tasks to better understand stress and alcohol related behaviors. MRI is required to detect significant brain abnormalities and for use in the PET image analysis. In Aim 1, Up to 30 PTSD and 30 TC will be imaged with \[18F\]Bavarostat to measure levels of HDAC6 throughout the brain to determine whether individuals with PTSD have altered levels of HDAC6 expression compared to trauma-exposed healthy controls. In Aim 2, Up to 30 AUD and 30 HC will be imaged with \[18F\]Bavarostat to measure levels of HDAC6 throughout the brain to determine whether individuals with AUD have altered levels of HDAC6 expression compared to healthy controls. In Aim 3, Up to 30 comorbid PTSD \& AUD subjects will be imaged with \[18F\]Bavarostat to measure levels of HDAC6 throughout the brain to determine whether individuals with comorbid PTSD \& AUD have altered levels of HDAC6 expression compared to trauma-exposed healthy controls.