Differences in Corneal Structure and Function in Patients With Sjogrens vs. Non-Sjogrens Dry Eye

Exclusion Criteria

• •● Age less than 18 years
• •* Physical or mental issues, illiteracy, or language problems that might possibly interfere with reading ability or other condition that would preclude successful participation in this study
• •* Contact lens wear within 10 days of enrollment
• •* Any intraocular surgery (including cataract surgery) within the last 3 months
• •* Any minor ocular surgery including tear duct cauterization or plugs within the last 30 days
• •* Any history of corneal surgery (including LASIK/PRK) or cosmetic lid surgery in the past 12 months
• •* Any history of glaucoma surgery (e.g., trabeculectomy or a tube shunt)
• •* Best corrected vision worse than 20/40
• •* Known history of severe ocular surface disease that might cause corneal haze and interfere with corneal staining score including but not limited to graft-versus-host disease, mucous membrane pemphigoid, atopic keratoconjunctivitis
• •* Presence of keratoconus
• •* Concurrent epithelial corneal disease or dystrophy (e.g., anterior basement membrane disease, pterygium, or scarring) that might affect the corneal staining score
• •* Previous use of OXERVATE® for neurotrophic keratitis
• •* Neurotrophic keratoconjunctivitis or corneal/conjunctival scarring (history of herpes simplex virus or varicella zoster virus keratitis)
• •* Any blepharitis eyelid procedures such as Intense Pulsed Light (IPL), low level light treatment therapy, LipiFlow®, or nasolacrimal duct probing in the last 30 days prior to the study visit
• •* Any acupuncture or physical therapy on the face or head within the past 3 months
• •* Current smoker (within the past year)
• •* Pregnant or nursing
• •* Artificial tear use within 2 hours of study visit
• •* Topical ophthalmic non-steroidal anti-inflammatory drug use 24 hours before the study visit
• •* History of taking or current use of topical glaucoma drops or neurostimulation drugs or devices for treating dry eye
• •* History or current intravitreal injections for macular degeneration
• •* History of continuous positive airway pressure usage in the past 3 months
• •* Any concurrent medical condition that in the judgment of the PI might interfere with the conduct of the study, confound the interpretation of the study results.