Confirmed diagnosis of pancreatic ductal adenocarcinoma (PDAC).
Resectable primary tumor based on triphasic CT-scan.
≤ 3 liver metastases.
Liver resections can be performed by local excision or non-anatomical, partial hepatectomy. Patients with complete radiologic response after neoadjuvant FOLFIRINOX (FFX), therefore not requiring liver resection, will be included.
No evidence of extrahepatic metastases.
Patient fit for pancreatic resection (ECOG 0 or 1).
Stable or partial response on imaging after neoadjuvant FFX.
No new metastasis after neoadjuvant FFX
Blood tumor markers ≥ 80% decreased or within normal values after neoadjuvant FFX.
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Impossibility to obtain tissue diagnosis preoperatively confirming PDAC.
Locally advanced disease on triphasic CT-scan.
\> 3 liver metastases.
Major hepatectomy required for liver metastases (right hepatectomy, left hepatectomy, central hepatectomy, extended right or left hepatectomy).
Suspicion or confirmation of extrahepatic metastases.
Patient unfit for pancreatic resection (ECOG 2 or more).
