Demonstrating Efficacy of JOGO for the Treatment of Tremor

Exclusion Criteria

• •Cognitive impairment (Montreal Cognitive Assessment greater than 26).
• •Currently taking any of the following medications to treat tremor: primidone, gabapentin, zonisamide, any non-selective beta blocker, any benzodiazepine.
• •Exposure to tremorgenic drugs or drug with withdrawal states within 30 days prior to the study start.
• •Direct or indirect trauma to the nervous system within 3 months preceding the onset of tremor.
• •Known history of other medical or neurological conditions that may cause or explain subject's tremor, including, but not limited to: Parkinson's disease, dystonia, cerebellar disease, traumatic brain injury, alcohol abuse or withdrawal, mercury poisoning, hyperthyroidism, pheochromocytoma, head trauma or cerebrovascular disease within 3 months prior to the onset of essential tremor, multiple sclerosis, polyneuropathy, family history of Fragile X syndrome.
• •Prior MR-guided focused ultrasound or surgical intervention (e.g., deep brain stimulation, ablative thalamotomy or gamma knife thalamotomy).
• •Botulinum toxin injection in the 6 months prior to screening.
• •Use of medication(s) in the past month that might produce tremor or interfere with the evaluation of tremor, such as, but not limited to: CNS-stimulants, lithium, amiodarone, metoclopramide, theophylline, and valproate.
• •Regular use of more than two units of alcohol per day.
• •Sporadic use of a benzodiazepine, sleep medication or anxiolytic to improve sleep performance. Stable use at a consistent dose is allowed if tremor persists against the background of regular medication use.
• •Current treatment with any investigational therapy for tremor.