Cellular, Molecular and Clinical Determinants of Bone Strength in in Vivo and Human Models of GH Excess.

Exclusion Criteria

• •Pregnancy
• •use of glucocorticoids (except those in use for replacement therapy)
• •alcohol abuse
• •exacerbation of chronic disease
• •serious comorbidities (renal or hepatic failure, heart attack, stroke)
• •terminally ill, prolonged immobilization (\>1 week)
• •clinically evident fracture within the previous six months
• •any other cause of secondary osteoporosis within the last five years
• •any prolonged treatment with drugs with documented influence on bone metabolism during the previous 12 months, including treatment with antiresorptive or anabolic compounds for osteoporosis.