Vibration Training Approach in Liver Cirrhosis

Inclusion Criteria

• •Patients with confirmed or newly diagnosed compensated liver cirrhosis suffering from sarcopenia (combined decrease in muscle mass and muscle strength)
• •The liver cirrhosis is in a compensated stage.
• •The following etiologies of chronic liver disease are present: chronic hepatitis B infection, chronic hepatitis C infection, alcoholic liver disease, autoimmune hepatitis, cholestatic liver disease (PBC, PSC), or other chronic hepatopathy.
• •Alcohol abstinence of at least 3 months in cases of alcohol-related liver disease.
• •Routine cancer screening for the presence of a liver tumor (HCC surveillance) is routinely performed using MRI or CT scans, as ultrasound assessment is severely limited.
• •Permission from the treating physician to engage in physical activity.
• •Signed informed consent form.
• •Patients with recent hospitalizations (within the last 3 months) due to gastrointestinal bleeding, hepatic encephalopathy, or spontaneous bacterial peritonitis
• •Presence of inadequately treated portal hypertension
• •Known chronic liver disease not described in the above groups
• •Alcohol consumption \>20 g per day
• •Excessive alcohol consumption during the study period leads to exclusion from the study
• •Substance abuse
• •Taking medications known to affect muscle mass or strength (e.g., Amiodarone, Chloroquine, Macrolides)
• •Taking medications known to cause movement disorders (e.g., Reserpine, Lithium, Cyclosporine A, Dopamine agonists)
• •Patients with unstable cardiovascular diseases: e.g., unstable angina pectoris, uncontrolled hypertension (≥ 160/100 mmHg), uncontrolled diabetes (blood sugar \> 250 mg/dl), history of myocardial infarction or stroke
• •Patients with musculoskeletal deformities, symptomatic rheumatoid or osteoarthritis
• •Patients with untreated or newly diagnosed active malignant tumors in history
• •Patients with neuromuscular or neurodegenerative diseases
• •Patients with untreated hernias
• •Patients with symptomatic, known untreated aortic aneurysm, with recent hospitalizations (within the last 6 months)
• •Patients with fractures within the last 12 months
• •Participation in moderate-intensity training programs for more than 2 hours per week
• •Patients who have received chemotherapy at the time of the study or in the past 3 months
• •Other underlying conditions that contraindicate vibration training and/or functional performance tests
• •Circumstances preventing the individual from assessing the nature, scope, and possible consequences of the clinical trial
• •Signs indicating that the subject is likely not to adhere to the study protocol (e.g., lack of cooperation)
• •a. Definition of hepatic decompensation
• •Occurrence of symptomatic ascites, hepatic encephalopathy, portal hypertensive bleeding (e.g., esophageal variceal bleeding), infection