Molecular Signatures Associated With Response to ICS Treatment in Patients With COPD Stratified by Eosinophil Levels

Exclusion Criteria

• •Presence of other respiratory disorders, (i.e. current physician diagnosis of asthma, early life history of asthma (\<21 years) a previous clinical diagnosis of bronchiectasis, interstitial lung disease, pulmonary eosinophilia).
• •Long-term oxygen therapy or non-invasive mechanical ventilation at home.
• •Current smokers.
• •Active cancer.
• •Use of ICS in the 3 months prior to the recruitment.
• •Participating in another randomized trial.
• •Not likely to complete the study.
• •Pregnant or breastfeeding females.
• •Exacerbations in the previous 8 weeks.
• •Primary or secondary immunodeficiency.
• •Immunosuppression or regular oral corticosteroid treatment.
• •Allergy to IMP's excipients.
• •Any circumstances which could contradict study participation and lead the investigator to assess the patient as unsuitable for study participation for any other reason.