An Adapted Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Familial Hypercholesterolemia (DICA-FH)

Exclusion Criteria

• •Having a "possible" FH result according to the Dutch MEDPED criteria;
• •TG ≥ 500mg/dL up to 6 months before screening for the study;
• •Diagnosis of hypercholesterolemia due to a secondary cause recorded in the medical record;
• •Food allergies (foods, dyes, preservatives);
• •Contraindication to the use of phytosterols (for example: diagnosis of sitosterolemia);
• •HIV positive on treatment with detectable viral load or AIDS;
• •Chronic inflammatory or autoimmune diseases;
• •Known liver disease, chronic kidney disease on dialysis or pancreatitis (acute and chronic);
• •Cancer being treated or life expectancy \< 6 months;
• •Episode of acute coronary syndrome in the last 60 days;
• •Chemical dependency/alcoholism;
• •Chronic use of anti-inflammatories, anticonvulsants and immunosuppressive drugs;
• •Use of PCSK9 inhibitors (alirocumab, evolocumab, inclisiran);
• •Pregnancy or lactation;
• •Individuals who are unable to perform an anthropometric assessment, at the discretion of the investigator;
• •Grade III/severe obesity (body mass index \[BMI\] ≥40kg/m² for adults or percentile \>99.9 or z-score \>+3 according to WHO/2006 growth curves for BMI/Age indicator for adolescents);
• •Use of dietary supplements that may interfere with the outcomes of interest (dietary fiber modules, n-3 PUFA, essential fatty acids);
• •Participation in other randomized clinical trials;
• •Refusal to participate in the study, due to failure to sign the Free and Informed Consent Form.