Assessment of the Safety and Efficacy of Balstilimab in Combination With Botensilimab for the Treatment of Non-Small Cell Lung Cancer (IMMONC0008)

This is a single-arm, open-label phase II study to evaluate the safety and efficacy of the combination of botensilimab and balstilimab in participants with metastatic non-small cell lung cancer (NSCLC). The study will enroll participants with a histologically confirmed diagnosis of metastatic NSCLC and without targetable EGFR mutation or ALK rearrangement, while excluding those with untreated brain metastases or oligometastatic disease lacking targetable lesions. The total estimated maximum time of study participation for each patient is approximately 49 months across 3 periods: * Screening Period: approximately 28 days * Treatment Period: up to 24 months, or until any criterion for stopping the study drug or withdrawal from the study occurs * Follow-up Period: up to 24 months from last dose of study treatment for every patient who is alive Study Duration * Recruitment: 2 years * Treatment: 2 years * Follow-up: 2 years