Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke

Exclusion Criteria

• •1. Patients who refuse participation in the study.
• •2. Patients with gross anatomical variances in MR imaging or cerebral vascular accidents involving thalamic and cerebellar areas.
• •3. Patients with no clinical condition to undergo DBS implantation or highly dependent on anticoagulation therapy.
• •4. Patients who cannot undergo pre-operative MRIs or could not complete the pre-operative assessments.
• •5. Participants must not have any serious disease or disorder (ex. neurological condition other than stroke, cancer, severe cardiac or respiratory disease, renal failure, etc.) or cognitive impairments that could affect their ability to participate in this study.
• •6. Female participants of child-bearing age must not be pregnant, planning to become pregnant for the next 9 months, or breast feeding.
• •7. Participants must not be receiving anticoagulants.
• •8. Severe claustrophobia.
• •9. Participants must not be on anti-spasticity or anti-epileptic medications for the duration of the study.
• •10. Participants who have been deemed inappropriate for participation based upon results from the Brief Symptoms Inventory (BSI-18) and discussions with the Principal Investigator and a study physician
• •11. Evaluation to sign consent form score \<12.
• •12. MRI contraindications (excluding subjects who are pregnant, who have metal in any portion of their body, have medical complications, cardiac pacemaker, cochlear implant, aneurysm clip, certain IUDs, or known problems of claustrophobia).
• •13. Medications with common cognitive side-effects.
• •14. Bleeding disorders or platelet dysfunction (e.g., from regular aspirin usage).
• •15. Patients must not have any lesions in the lower motoneuron causing flaccid dysarthria.